Zostum 3gm Injection

Zostum 3gm Injection contains Cefoperazone (2gm) and Sulbactam (1gm), a combination antibiotic used to treat a wide range of severe bacterial infections.

Benefits

This medicine helps treat a wide range of serious bacterial infections by stopping the spread of infection and supporting the body's recovery. It reduces symptoms such as fever, pain, swelling, and discomfort caused by infection. The combination is particularly effective against multidrug-resistant bacteria by inhibiting bacterial cell wall synthesis and counteracting beta-lactamase-mediated resistance.

Uses and Indications

• Severe respiratory tract infections, including pneumonia and bronchitis.
• Urinary tract infections (upper and lower), including complicated cases.
• Intra-abdominal infections such as peritonitis, appendicitis, cholecystitis, and cholangitis.
• Septicaemia (serious bloodstream infections).
• Meningitis (inflammation of the brain and spinal cord membranes).
• Skin and soft tissue infections, including cellulitis, diabetic foot infections, and abscesses.
• Bone and joint infections, such as osteomyelitis.
• Gynaecological infections, including pelvic inflammatory disease, endometritis, and gonorrhoea.

The Zostum 3gm Injection contains:

• Cefoperazone IP 2 gm (active ingredient).
• Sulbactam IP 1 gm (active ingredient).

Dosage and Administration

Zostum 3gm Injection is administered by a qualified doctor or nurse, either intravenously (into a vein) or intramuscularly (into a muscle). The specific dose and duration of treatment will be determined by the prescribing doctor based on the type and severity of the infection, the patient's weight, age, and kidney or liver function. It is typically given in equally divided doses every 12 hours. For intravenous infusion, the vial is reconstituted with a suitable solution (e.g., sterile water for injection, 0.9% Sodium Chloride, or 5% Dextrose in Water) and then diluted for administration over 15 to 60 minutes. For direct intravenous injection, it is reconstituted and administered over a minimum of 3 minutes. Do not self-inject this medicine.

Storage and Disposal

• Store below 25°C.
• Protect from light and moisture.
• Keep out of reach of children.

Precautions and Safety

• Inform your doctor if you have a history of severe allergic reactions to antibiotics, especially penicillins or cephalosporins.
• Exercise caution if you have liver or kidney disease, as dosage adjustments may be necessary.
• Tell your doctor if you are taking blood-thinning medicines (oral anti-coagulants like warfarin) or if you experience abnormal bleeding.
• Report any severe, watery, or bloody diarrhoea that occurs during or after treatment.
• Avoid alcohol consumption during treatment and for at least five days after the last dose, as it can cause adverse reactions like flushing, sweating, headache, and increased heartbeats.
• Inform your doctor about any poor diet, malabsorption conditions, or upcoming laboratory tests.
• Pregnant and breastfeeding women should use this medicine only if specifically advised by their doctor.
• Complete the full prescribed course of treatment, even if symptoms improve.

Side Effects and Risks

• Common side effects include loose stools or diarrhoea, nausea, vomiting, headache, fever, chills, and allergic reactions.
• Pain, tenderness, inflammation, or swelling at the injection site, along with skin rashes, may occur.
• Rare but serious side effects can include severe skin reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome), persistent bleeding, and neurological effects like seizures in cases of overdose.

Disclaimer

Use this medicine only under the prescription and guidance of a qualified doctor or pharmacist.