Smofkabiven Peri 1448ml Injection

Smofkabiven Peri 1448ml Injection is an emulsion for infusion that provides essential amino acids, glucose, lipids, and electrolytes. It is used for parenteral nutrition when a patient's gastrointestinal tract cannot be used, is insufficient, or is contraindicated.

Benefits

This intravenous nutritional support system offers complete nutritional support by delivering essential macronutrients and, when prescribed, micronutrients in a single infusion. It simplifies administration by combining nutrients in one formulation, potentially reducing the need for multiple infusion lines. The lipid component helps prevent essential fatty acid deficiency and supports overall tissue repair and recovery.

Uses and Indications

• Nutritional deficiencies when oral or enteral feeding is impossible, insufficient, or contraindicated.
• Short bowel syndrome, where the remaining intestine cannot absorb adequate nutrients.
• Severe malabsorption conditions, such as severe Crohn's disease or radiation enteritis.
• Bowel obstruction, preventing the passage of food through the digestive tract.
• Hypermetabolic states, including major burns, severe trauma, or sepsis, requiring high caloric intake.
• Gastrointestinal fistulas, to provide nutrition while allowing the digestive tract to rest and heal.
• Support for critically ill patients who cannot tolerate enteral (tube) feeding.

The Smofkabiven Peri 1448ml Injection contains a comprehensive blend of active ingredients, including:

• Amino Acids: Alanine, Arginine, Glycine, Histidine, Isoleucine, Leucine, Lysine (as acetate), Methionine, Phenylalanine, Proline, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Valine.
• Glucose: Glucose (as monohydrate).
• Lipids: Soya-bean oil (refined), Medium-chain triglycerides, Olive oil (refined), Fish oil (rich in omega-3-acids).
• Electrolytes: Calcium chloride (as dihydrate), Sodium glycerophosphate (as hydrate), Magnesium sulphate (as heptahydrate), Potassium chloride, Sodium acetate (as trihydrate), Zinc sulphate (as heptahydrate).

Dosage and Administration

Smofkabiven Peri 1448ml Injection is administered intravenously by a healthcare professional. The dose is individualized based on the patient's body weight, clinical condition, and nutritional requirements. The recommended infusion period typically ranges from 14 to 24 hours. The maximum infusion rate should not exceed 3.0 ml/kg body weight per hour. It can be infused into either a peripheral or a central vein.

Storage and Disposal

• Store the product in its overpouch below 25°C. Do not freeze.
• Keep this medicine out of the sight and reach of children.
• This product is for single use only. Any unused solution remaining after infusion should be discarded.

Precautions and Safety

• Inform your doctor if you have known allergies to fish, egg, peanuts, or soya, as this product contains soya-bean oil, fish oil, and egg phospholipids.
• Use with caution in patients with impaired lipid metabolism, which may occur in conditions such as renal failure, diabetes mellitus, pancreatitis, impaired liver function, hypothyroidism, and sepsis.
• Close monitoring of serum glucose, electrolytes, osmolarity, fluid balance, acid-base status, and liver enzyme tests is required. Blood cell count and coagulation should be monitored during long-term lipid administration.
• Strict aseptic precautions are necessary during catheter insertion and manipulation to minimize the risk of infection.
• In patients with hyperglycemia, exogenous insulin administration may be necessary.
• Thrombophlebitis can occur with peripheral vein infusions; the catheter site should be evaluated daily.

Side Effects and Risks

• Common side effects include a slightly raised body temperature.
• Uncommon side effects may include high blood levels of liver compounds, lack of appetite, nausea, vomiting, chills, dizziness, and headache.
• Rare side effects reported are low or high blood pressure, difficulty in breathing, fast heart beat (tachycardia), and hypersensitivity reactions (e.g., skin rash, swelling, fever).
• Overdose or impaired triglyceride elimination can lead to "Fat overload syndrome," characterized by hyperlipemia, fever, and abnormal liver function tests.
• Injection site inflammation (redness, swelling, and pain) may occur.

Disclaimer

Use this medicine only under the prescription and guidance of a qualified doctor or pharmacist.