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Varilrix 0.5ml Injection
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Brand Glaxo Smith Kline
Varilrix 0.5ml Injection is a live attenuated varicella vaccine, containing the Oka-strain of the varicella-zoster virus, designed for active immunization against chickenpox. Each 0.5 mL dose of the reconstituted vaccine contains not less than 103.3 plaque-forming units (PFU) of the varicella-zoster virus. This vaccine is indicated for healthy individuals from 9 months of age and older, including children, adolescents, and adults, as well as susceptible high-risk patients and their close contacts.
The vaccine is supplied as a lyophilized powder and a sterile diluent (water for injection), which must be reconstituted prior to administration. Varilrix 0.5ml Injection is administered via subcutaneous (SC) injection, typically into the deltoid region of the upper arm or the anterolateral area of the thigh. It is crucial that the vaccine is not administered intravascularly or intradermally.
Proper cold-chain management is essential for Varilrix. The lyophilized vaccine requires refrigerated storage between 2°C and 8°C and must be protected from light. The accompanying diluent can be stored either in the refrigerator or at ambient temperature, up to a maximum of 25°C. After reconstitution, the vaccine should be injected promptly; however, it can be stored for up to 90 minutes at room temperature (25°C) or up to 8 hours in the refrigerator (2°C to 8°C) if immediate use is not possible.
Key Features :
Antigen Composition: Contains live attenuated Oka-strain of varicella-zoster virus for active immunization against chickenpox.
Approved Indications and Target Population: Indicated for healthy individuals from 9 months of age and older, including children, adolescents, adults, and susceptible high-risk contacts.
Cold-chain Storage: Lyophilized vaccine requires storage at 2°C to 8°C, protected from light.
Route and Schedule: Administered via subcutaneous injection; children (9 months to 12 years) receive two doses at least 6 weeks apart (not less than 4 weeks), while adolescents and adults (13 years and older) receive two 0.5 mL doses with a minimum interval of 6 weeks (not less than 4 weeks).
Regulatory Approval: WHO Prequalified and meets WHO requirements for biological substances and varicella vaccines.