Cresp 60mcg 0.3ml PFS Injection

Cresp 60mcg 0.3ml PFS Injection contains Darbepoetin alfa, an erythropoiesis-stimulating agent used to treat anemia associated with chronic kidney disease and chemotherapy.

Benefits

This injection stimulates the bone marrow to produce red blood cells, which helps increase hemoglobin levels. It effectively reduces symptoms of anemia such as tiredness and weakness, thereby improving the overall quality of life for patients. Due to its longer half-life, Cresp allows for less frequent dosing compared to conventional erythropoietin therapies.

Uses and Indications

• Treatment of anemia due to chronic kidney disease (CKD) in both dialysis and non-dialysis patients.
• Management of anemia caused by chemotherapy in adult cancer patients with non-myeloid malignancies.

The Cresp 60mcg 0.3ml PFS Injection contains:

• Darbepoetin alfa (r-DNA Origin) 60mcg (active ingredient).
• Excipients: sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous, sodium chloride, polysorbate 80, water for injection.

Dosage and Administration

Cresp 60mcg 0.3ml PFS Injection is administered as a subcutaneous (under the skin) or intravenous (into a vein) injection. The dose is individualized by a healthcare provider based on the patient's body weight and hemoglobin levels. Patients should not self-administer this medicine unless properly trained by a doctor or nurse. Avoid frequent dose adjustments. The lowest effective dose should be used to minimize the need for red blood cell transfusions.

Storage and Disposal

• Store in a refrigerator between 2°C to 8°C (36°F to 46°F).
• Do not freeze or shake the injection.
• Protect from light; store in the original carton until use.
• Once removed from the refrigerator and at room temperature (up to 25°C), it must be used within 7 days or disposed of.
• Do not reuse single-dose pre-filled syringes; dispose of any remaining medicine safely.
• Keep out of reach of children.

Precautions and Safety

• This medicine is prescription-only and must be used under strict medical supervision.
• Regular monitoring of blood pressure is essential, as hypertension is a common side effect.
• There is an increased risk of serious cardiovascular events, stroke, and blood clots, particularly if hemoglobin levels are targeted too high (above 11 g/dL).
• In certain cancer patients, this medicine may increase the risk of tumor progression or shorten survival time. Your healthcare provider will discuss these risks.
• Serious allergic reactions, including anaphylaxis, can occur. Seek immediate medical attention if you experience symptoms like rash, itching, swelling of the face, tongue, or throat, or trouble breathing.
• Serious skin reactions, such as blistering or peeling, have been reported.
• Inform your doctor about any history of seizures, epilepsy, liver disease, or known allergies.
• Cresp is not intended for immediate correction of severe anemia or emergency transfusions.
• Other causes of anemia, such as iron deficiency, should be corrected as necessary.

Side Effects and Risks

• Common side effects include hypertension (high blood pressure), edema (swelling), fatigue, pain at the injection site, diarrhea or constipation, fever, headache, cough, and stomach pain.
• Serious but less frequent adverse reactions can include blood clots, heart attack, stroke, heart failure, seizures, and severe allergic reactions.
• Rarely, the medication may stop working effectively due to the body producing antibodies, which can lead to severe anemia.

Disclaimer

Use this medicine only under the prescription and guidance of a qualified doctor or pharmacist.