Metoclopramide 2ml Injection

Metoclopramide 2ml Injection contains Metoclopramide 10 mg, an anti-emetic and prokinetic agent primarily used to prevent and treat nausea and vomiting.

Benefits

This injection provides effective relief from persistent nausea and vomiting, which helps patients maintain adequate food and fluid intake. It works by speeding up the movement of food through the stomach and intestines. It is particularly useful in managing nausea and vomiting associated with various medical conditions, including post-surgical recovery, chemotherapy, and radiotherapy.

Uses and Indications

• Prevention of postoperative nausea and vomiting (PONV).
• Symptomatic treatment of nausea and vomiting, including those associated with acute migraine.
• Prevention of delayed chemotherapy-induced nausea and vomiting (CINV) and radiotherapy-induced nausea and vomiting (RINV).
• Relief of symptoms related to diabetic gastroparesis (slow stomach emptying).
• To facilitate small bowel intubation in diagnostic procedures.

The Metoclopramide 2ml Injection contains:

• Metoclopramide hydrochloride 10 mg/2 mL (equivalent to Metoclopramide base 5 mg/mL) (active ingredient).
• Sodium chloride.
• Water for Injection.
• pH adjusted with hydrochloric acid and/or sodium hydroxide.

Dosage and Administration

1. Metoclopramide 2ml Injection is administered either intramuscularly (IM) or by slow intravenous (IV) injection.
2. Intravenous doses should be administered slowly over at least 1 to 2 minutes, or as a slow bolus over at least 3 minutes, to minimize the risk of adverse effects.
3. For adults, a single dose of 10 mg is recommended for the prevention of postoperative nausea and vomiting.
4. For symptomatic treatment of nausea and vomiting (including migraine-induced) and radiotherapy-induced nausea and vomiting, the recommended single dose is 10 mg, repeated up to three times daily. The maximum recommended daily dose is 30 mg or 0.5 mg/kg body weight.
5. The maximum recommended treatment duration is 5 days for all age groups.
6. Dosage adjustments may be necessary for patients with renal or severe hepatic impairment; consult a doctor for specific guidance.

Storage and Disposal

• Store the injection below 25°C and protect it from light. Keep it in its carton until the time of use.
• Inspect the solution before use; discard if any color change or particulate matter is observed.
• Discard any unused portion of the injection.
• If diluted for intravenous administration, prepare under aseptic conditions and use within 24 hours if unprotected from light, or up to 48 hours if protected from light.
• Keep out of reach of children.

Precautions and Safety

• Do not use Metoclopramide 2ml Injection for longer than 12 weeks due to the increased risk of developing tardive dyskinesia, a potentially irreversible movement disorder.
• Avoid consuming alcohol during treatment, as it can enhance the sedative effects of this medicine.
• Exercise caution in patients with a history of depression, high blood pressure, asthma, kidney disease, or cardiac conduction disturbances.
• This medicine is contraindicated in individuals with epilepsy, Parkinson's disease, gastrointestinal bleeding, obstruction or perforation, or a tumor of the adrenal gland (pheochromocytoma).
• Metoclopramide 2ml Injection is not recommended for use in children under 1 year of age.
• Monitor for symptoms of Neuroleptic Malignant Syndrome (NMS), such as high fever, severe muscle stiffness, and irregular heartbeat, and seek immediate medical attention if they occur.
• This medicine may cause drowsiness, dizziness, or light-headedness; avoid driving or operating heavy machinery until you know how it affects you.

Side Effects and Risks

• Common side effects include drowsiness, tiredness, restlessness, dizziness, headache, and diarrhea.
• Serious side effects can include tardive dyskinesia (uncontrollable muscle movements, especially of the face), extrapyramidal symptoms (shaking, tremor, stiffness, involuntary movements), depression (including suicidal ideation), Neuroleptic Malignant Syndrome (NMS), seizures, and allergic reactions (rash, swelling, difficulty breathing).
• If any serious side effects occur, discontinue use and seek immediate medical advice.

Disclaimer

Use this medicine only under the prescription and guidance of a qualified doctor or pharmacist.