Adreford 1ml Injection

Adreford 1ml Injection contains Adrenaline Bitartrate 1mg, a potent medication used for the emergency treatment of severe allergic reactions and cardiac arrest.

Benefits

Adrenaline acts as an alpha- and beta-adrenergic agonist, relaxing muscles in the lungs to relieve spasm, wheezing, and shortness of breath during severe allergic reactions (anaphylaxis). It also stimulates the heart and raises blood pressure, which is crucial in life-threatening emergencies.

Uses and Indications

• Emergency treatment of severe allergic reactions (anaphylaxis).
• Management of cardiac arrest.
• Symptomatic relief of respiratory distress due to bronchospasm.

The Adreford 1ml Injection contains:

• Adrenaline (Epinephrine) as acid tartrate 1mg per ml (active ingredient).
• Excipients: Sodium Chloride, Sodium Metabisulphite, and Water for Injections. Hydrochloric acid and/or sodium hydroxide may be added to adjust acidity.

Dosage and Administration

1. For Anaphylaxis (Adults): Typically, 0.3 to 0.5 mg (0.3 to 0.5 mL of 1:1000 solution) administered intramuscularly into the anterolateral aspect of the thigh. This dose may be repeated every 5 to 15 minutes as needed.
2. For Anaphylaxis (Children): 0.01 mg/kg (0.01 mL/kg) intramuscularly, up to a maximum of 0.3 mg (0.3 mL) per injection for children under 30 kg, and 0.3 to 0.5 mg (0.3 to 0.5 mL) for children 30 kg or more. Repeat every 5 to 15 minutes as necessary.
3. For Cardiac Arrest (Adults): 1 mg intravenously or intraosseously, repeated every 3 to 5 minutes. The 1mg/ml (1:1000) solution must be diluted to 1:10,000 (0.1 mg/ml) for intravenous use.
4. General Administration: The exact dosage and route of administration must be determined by a qualified doctor or healthcare professional based on the patient's condition. Intramuscular injection into the buttocks, fingers, toes, ears, nose, or genitalia should be avoided due to the risk of tissue necrosis.

Storage and Disposal

• Store below 25°C (68°F to 77°F), protected from light and freezing.
• Keep in the original outer carton to protect from light.
• Do not use if the solution is discolored, cloudy, or contains particulate matter.
• Discard any unused portion after opening.
• Keep out of the sight and reach of children.

Precautions and Safety

• Continuous medical supervision is necessary after administration.
• Use with caution in elderly patients and those with pre-existing heart conditions, hyperthyroidism, diabetes, glaucoma, high blood pressure, or kidney disease.
• Accidental intravascular injection of the 1mg/ml solution can cause severe hypertension, potentially leading to cerebral hemorrhage.
• Repeated local injections may cause tissue necrosis at the injection site due to vascular constriction.
• This medicine contains Sodium Metabisulphite, which may cause allergic reactions, especially in individuals with a history of asthma or allergies.
• Adrenaline should only be used during pregnancy and breastfeeding if considered essential by a doctor.

Side Effects and Risks

• Common side effects include palpitations, tremors, anxiety, dizziness, pale skin, headache, weakness, sweating, nausea, vomiting, and respiratory difficulties.
• More serious side effects can include rapid or irregular heartbeat, high blood pressure, chest pain, and in rare cases, cerebral hemorrhage or pulmonary oedema.
• Report any sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash, or itching (especially affecting the whole body) immediately to a doctor.

Disclaimer

Use this medicine only under the prescription and guidance of a qualified doctor or pharmacist.