A Method of Producing Colchicine from an Endophytic Phomopsis Using Epigenetic Modifiers

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MBKIHT0071
Features : " e-Auction Description of Work : A Method of Producing Colchicine from an Endophytic Phomopsis Using Epigenetic Modifiers " e-Auction Type : NonExclusive " e-Auction Number : NE/KIHT/20059 " TRL : 5 " Base Price : 400000.00 " e-Auction Date / Time : 30-11-2018 16:02 " Repeated sub-culturing of fungi leads to a process called attenuation and one of the reasons could be silencing of the genes. Epigenetics being one of the prime mechanism in silencing of functional genes, its role in attenuation of metabolite synthesis was analyzed. " The method employed will prevent attenuation of the metabolite production and induce production of the metabolite in axenic cultures " We have established the method with our fungal culture which showed attenuation of metabolite production. The method employed has resulted in production of attenuated metabolite in the axenic culture system Need & Demand : " Attenuation is one of the phenomenon which leads to a partial loss of a property of a given isolate. Attenuation plays a very important role in those fungi which are capable of producing host specific phyto-chemicals. The present proposed invention states a way in overcoming the attenuated stage of the fungal endophyte Market Access Information : " The product formed by this method, colchicine, has well known medical applications and is marketed in the USA and other countries under various trade names, though under some legal cloud. " The method developed can be adapted for several other important metabolites of marketable nature. Future Developments : " Large scale preparation needs to be optimised " Similar methods can be extrapolated to other products
A Method of Producing Colchicine from an Endophytic Phomopsis Using Epigenetic Modifiers
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